This is a list of celebrities who have appeared or been parodied on the Comedy Central animated series South Park. An asterisk (*) denotes that the celebrity is deceased.

Actors and comedians, past and present

• Ben Affleck
• Jennifer Aniston (ep. 303 Rainforest Schmainforest)
• Cheech and Chong (ep. 407, Cherokee Hair Tampons)
• George Clooney (ep. 104, as Stan's gay dog, 'Big Gay Al's Big Gay Boat Ride')
• Bill Cosby
• Russell Crowe (ep. 604, in The New Terrance and Phillip Trailer)
• Bob Denver
• Celine Dion (ep. 201, in Terrance and Phillip in Not Without my Anus)
• Michael Dorn (ep. 605, as Worf from Star Trek)
• Patrick Duffy
• Buddy Ebsen* (as Barnaby Jones)
• Mel Gibson (ep. 804, The Passion of the Jew)
• Whoopi Goldberg, in the 'Spontaneous Combustion' episode:"I hate Republicans"
• Tom Green
• Gene Hackman
• Tom Hanks (who, according to Cartman, "can't act his way out of a nutsack")
• Natasha Henstridge (as "Miss Ellen" in ep. 111, Tom's Rhinoplasty; credited as "The Chick from Species")
• Jay Leno (as himself in a Thanksgiving short presented in 1997 on The Tonight Show)
• Malcolm McDowell (live action; ep. 405, Great Expectorations)
• Walter Matthau*
• Josh Meyers
• Ricardo Montalban
• Nick Nolte, in the 'Spontaneous Combustion' episode, as announcer for Nobel Prizes
• Pat O'Brien
• Rosie O'Donnell ('ep. 413, Trapper Keeper')
• Sidney Poitier
• Christopher Reeve*
• Carl Reiner
• Rob Reiner
• Bob Saget
• Will and Jada Pinkett Smith
• Suzanne Sommers
• Sonny* and Cher
• Richard Stamos (John Stamos's not-so-famous brother)
• Barbara Streisand
• Sally Struthers (Several times, including Starvin' Marvin and Starvin' Marvin in Space)
• John Travolta
• Henry Winkler (as Arthur Fonzarelli, aka "The Fonz")
• Tina Yothers

Musical performers/musicians

• Christina Aguilera
• Phil Collins
• Ronnie James Dio
• Fleetwood Mac
• Philip Glass
• Isaac Hayes (voice of "Chef")
• Alan Jackson
• Rick James*
• Elton John (credited as Sir Elton John)
• Kenny G
• Kid Rock
• KoRn
• Lil Kim
• Jennifer Lopez
• Marilyn Manson
• Meat Loaf
• Metallica (James Hetfield and Lars Ulrich)
• Alanis Morrisette
• Ozzy Osbourne
• P. Diddy
• Primus
• Rancid
• Radiohead
• Robert Smith (The Cure)
• Snoop Dogg
• Britney Spears
• Rod Stewart
• Barbara Streisand
• Joe Strummer* of The Clash
• Justin Timberlake
• Ween
• Yoko Ono

Sports personalities

• Barry Bonds
• Kobe Bryant
• John Elway (with the 1989/1991 Denver Broncos)
• Mark McGwire
• Jason Giambi
• Brent Musberger
• O.J. Simpson

Miscellaneous personalities, past and present

• John Adams*
• Osama bin Laden
• David Blaine
• John Wilkes Booth (as a statue)*
• George H.W. Bush
• George W. Bush
• Bill Clinton
• Gary Condit (Congressman from California involved in the 2001 disappearance of Chandra Levy)
• Francis Ford Coppola, film director
• John Dickinson*
• John Edward
• Steve Forbes
• Bill Gates
• Kathie Lee Gifford
• Al Gore
• Paris Hilton
• Saddam Hussein (with a Terrance & Phillip-style body)
• Rev. Jesse Jackson
• Thomas Jefferson*
• Steve Jobs, founder of Apple Computer
• Larry King
• Ted Koppel, host of ABC's Nightline
• Krishna*
• Lao Tse*
• Jim Lehrer
• Abraham Lincoln (ep. 504 The Super Best Friends; he tries to attack the group after he "rises" from the Lincoln Memorial)*
• Kurt Loder
• George Lucas, film director
• Leonard Maltin
• Muhammad*
• Bill O'Reilly
• Jack Osbourne (son of Ozzy)
• The Fab 5 from Queer Eye for the Straight Guy
• The parents of JonBenet Ramsey
• Charlie Rose
• Karl Rove (George W. Bush's senior advisor)
• Joseph Smith (founder of the Mormon church)^*
• Steven Spielberg
• Martha Stewart
• John Walsh (host of America's Most Wanted)
• Oprah Winfrey
• Brigham Young (first leader of the Mormon church)*