What is Monogenic? : Abaara fun facts and uncommon knowledge

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Monogenic

In genetics, monogenic genetic disorders are hereditary diseases that result from abnormalities in one (mono) gene. Inheritance can be either autosomal dominant, X-linked or recessive, but is generally more predictable than polygenic disorders, which in turn can vary in severity through combinations of several genes.

Examples of monogenic disorders are:

Cystic fibrosis - autosomal recessive
Sickle-cell anemia - autosomal recessive
Glucose-6-phosphate dehydrogenase deficiency (G6PD) - X-linked
Polycystic kidney disease - recessive and dominant forms

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Categories: Applied genetics